Myelodysplastic Syndrome

Myelodysplastic Syndrome

Myelodysplastic syndromes (MDS) are a group of disorders caused by dysfunctional bone marrow production which subsequently leads to poorly developed or dysfunctional blood cells.

MDS affects individuals of any ethnicity or gender. Age being a significant risk factor, MDS is most commonly diagnosed in persons above the age of 65. Additional risk factors can include being of South Asian descent.

Physical signs of MDS include: fatigue, pale skin, easy or unusual bruising or bleeding, pinpoint sized red spots beneath the skin, and frequent infections. The symptoms range from anemia to a shortage of platelets, and are often mistaken for signs of general aging or less serious conditions.

Diagnostics require blood tests and a bone marrow biopsy. Treatment includes medication or more extremely a blood transfusion.

1
Healthy blood
A
Abundant red blood cells
B
Lymphocytes
C
Monocytes
D
Neutrophils
E
Abundant platelet count
2
Cancerous blood
F
Reduced red blood cells
G
Ring sideroblasts
H
Neutrophils
I
Reduced platelet count
3
Refractory anemia with ringed sideroblasts
One example of a representative morphologic abnormality in myelodysplastic syndrome
4
Blood transfusion
5
Fatigue
6
Pale skin
7
Easy or unusual bruising and bleeding
8
Pinpoint sized red spots beneath the skin

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